Department of Neurology, University Hospital Zurich

Postdoctoral position bridging epigenetics, multi-omics and translational brain tumor research
100 %

We offer a postdoctoral position for an interdisciplinary project involving two laboratories at the University of Zurich and the University Hospital Zurich with the goal to understand the gene regulatory landscape that drives cancer evolution and treatment resistance in glioblastoma.

Your responsibilities

Glioblastoma is the most common and most aggressive primary brain tumor in adults, which poorly responds to current therapies and is inevitably fatal. Therefore, there is an urgent need for a better understanding of targetable molecular mechanisms at different disease stages and for novel treatment options. Epigenetic mechanisms are potential therapeutic targets due to their reversible nature. However, the gene regulatory landscape, comprising epigenetic alterations as well as transcriptional and chromatin regulators, in glioblastoma at different disease stages and upon chemotherapy and irradiation is largely unknown.

This project will address this gap of knowledge using cutting-edge technologies in genomics, single-cell transcriptomics and genome engineering as well as functional studies with state-of-the-art in vitro and in vivo models and patient samples. The project is carried out in the Laboratories of Prof. Dr. T. Baubec at the University of Zurich and Prof. Dr. M. Weller at the University Hospital Zurich and will involve interactions with different research groups and facilities from the research network of Zurich.

Your profile

Individuals must have a PhD or MD-PhD degree, strong computational skills, excellent written and oral communication skills and be prepared to work in a dynamic team environment. Experience in the following technical areas is preferred: genomics, molecular and cell biology.

What we offer

We offer varied and interesting work in an inspiring and socially relevant environment.
Diversity and inclusion are important to us.

Place of work


Start of employment

Earliest starting point is immediately and latest starting point is 1st of January 2020.

Please send your application to or (or using the 'apply now' button) and include the following information: a cover letter outlining your research interests, CV, publication list, contact information for two references.

Further information

Dr. med. Tobias Weiss