Post-doctoral position in Cancer Cell Biology funded by Krebsliga 70 %
With the support of the Krebsliga (Swiss Cancer League, a registered charity with mission to support cancer patients and cancer research in Switzerland), the groups of Prof. Cristina Nevado (Department of Chemistry), Prof. Raffaella Santoro (Department of Molecular Mechanisms of Disease) and Prof. Amedeo Caflisch (Department of Biochemistry) at the University of Zurich are seeking a cancer cell biologist at the post-doctoral level to support their successful program on drug discovery, with a particular focus on prostate cancer.
The successful candidate will join a highly interdisciplinary team involving medicinal chemists, biochemists and structural biologists working towards new approaches in prostate cancer treatment. The duties and activities of this position involve (but are not limited to):
Cytotoxicity and viability assays (cell, tissue), also in HTS format.
Characterization of molecular mechanism of action of small molecules.
Analysis of transcriptomics and proteomics data.
Dissection of signaling pathways relevant in cancer using chemical probes.
Proof of principle studies for target selection and validation.
Animal studies (in house, through collaboration or outsourced).
PK/PD characterization of compounds originating from medicinal chemistry program (previous exposure to pharmacology will be a plus).
The successful candidate will drive the project to develop and validate novel epigenetic modulators for the therapy of castration resistant prostate cancer. The role will also involve co-responsibility for the cell culture lab and for the training and supervision of junior group members in performing cell culture experiments.
We seek an enthusiastic individual with the ability to work both highly independently as well as in a team. In addition to relevant experience in the abovementioned activities, the candidate should have excellent project management and communication skills, as well as be fluent in English. The candidate should be about to receive their PhD degree or have less than two years of previous post-doctoral experience. Applications from senior researchers or senior post-docs will not be considered.
What we offer
Our well-funded drug discovery research program combines inspiring international research environment with access to state-of-the-art scientific infrastructure. Our alumni value their comprehensive training: approximately 30% of them take a tenure track group leader or Assistant Professorship position, with vast majority of the rest finding employment in pharmaceutical or biotech industry.
Place of work
Prof. Dr. Cristina Nevado University of Zurich Department of Chemistry Winterthurerstrasse 190 (Irchel Campus) CH-8057 Zurich
Start of employment
By arrangement (immediate entry possible). Applications of strongly motivated candidates containing in a single pdf file a cover letter, research summary of past accomplishments, CV (resumé), and 1 letter of support (or the names and contact details of 2 referees) should be sent per email to Prof. Dr. Cristina Nevado.