Several PhD Student positions are available in the research group of Prof. Dr. Peter Hamm at the Department of Chemistry, University of Zurich. The general topic of our work is the structure and dynamics of complex molecular systems investigated by ultrafast vibrational spectroscopy such as transient-IR spectroscopy, 2D IR spectroscopy and 2DRaman-THz spectroscopy.
Positions are available in two projects: First project: Dynamic response of allosteric proteins upon the photo-triggered unbinding of specifically designed ligands. To get a flavour of the first project, please have a look at the following publications:
B. Buchli, S. A. Waldauer, R. Walser, M. Donten, R. Pfister, N. Blöchliger, S. Steiner, A. Caflisch, O. Zerbe and P. Hamm, Kinetic response of a photo-perturbed allosteric protein, Proc. Natl. Acad. Sci. USA, 110 (2013) 11725-11730
G. Stock and P. Hamm, A Nonequilibrium Approach to Allosteric Communication, Philosophical Transactions B, 2018, 373, 20170187
B. Jankovic, A. Gulzar, C. Zanobini, O. Bozovic, S. Wolf, G. Stock, P. Hamm, Photocontrolling Protein-Peptide Interactions: From Minimal Perturbation to Complete Unbinding, J. Am. Chem. Soc., 2019, in press, http://dx.doi.org/10.1021/jacs.9b03222.
Second project: 2D-Raman-THz spectroscopy of super-cooled water and ionic liquids. This is a hardcore laser spectroscopy project, which will also involve the implementation of a newly purchased 100 kHz femtosecond laser. To get a flavour of the second project, please have a look at the following publications:
Shalit, S. Ahmed, J. Savolainen, and P. Hamm, THz echoes reveal the inhomogeneity of water in aqueous salt solutions, Nature Chem., 2017, 9, 273-278
A. Berger, G. Ciardi, P. Hamm and A. Shalit, The Impact of Nuclear Quantum Effects on the Structural Inhomogeneity of Liquid Water, Proc. Natl. Acad. Sci. USA, 2019, 116, 2458–2463
Besides a background in Physical Chemistry, a solid knowledge of standard Biochemistry techniques, in particular of protein expression, will be required for the first project, and experience with complex laser spectroscopic setups for the second project.
What we offer
We offer excellent research conditions, above-average salaries, the high quality of life in the city of Zurich and its surroundings, as well as the possibility to work in fascinating interdisciplinary research fields.
Place of work
University of Zurich Department of Chemistry Research Group of Prof. Dr. Peter Hamm
Start of employment
Employment start date to be mutually agreed. We look forward to receiving your application as a single PDF file including the following documents: a cover letter stating your motivation for this position, a CV and copies of degrees.