Department of Chemistry

PhD student position in chemical protein synthesis
60 %

A PhD student position is available in the group of Prof. Dr. Nina Hartrampf in the Department of Chemistry at University of Zurich (Switzerland). The group is interested in the development of new methods for the chemical synthesis and modification of peptides and proteins.
Peptides and proteins play crucial roles in every aspect of life. Their chemical synthesis allows for the incorporation of non-canonical amino acids, post-translational modifications, peptide backbone modifications, and functional handles. However, chemical peptide synthesis requires highly efficient transformations to ensure successful incorporation of every single building block. The Hartrampf group addresses these challenges by using flow-based synthesis methods.

Your responsibilities

The PhD project focuses on the chemical synthesis of a class of small regulatory proteins with potential therapeutic applications. A primary task will be the synthesis of novel non-canonical amino acid building blocks for application in flow-based solid-phases peptide synthesis (SPPS). In addition, a biochemical assay will be developed to characterize the binding of the synthesized peptides/proteins to their biological targets.

Your profile

We are looking for a highly motivated and enthusiastic Ph.D. student to join our young and dynamic research group. The candidate must hold an excellent Master degree in chemistry, biochemistry, or related field, and must be fluent in oral and written English. A strong background in synthetic organic chemistry, as well as experience with peptide and protein chemistry, protein expression, and/or flow chemistry is a plus.

What we offer

We offer an exciting position in a stimulating and challenging environment, and the opportunity to work with state-of-the-art SPPS technology, flow chemistry equipment, and new instrumentation for peptide purification and analysis. The candidate will be trained in chemical biology (chemical protein synthesis, synthetic organic chemistry and biological applications) and will benefit from high-profile interdisciplinary collaborations.

Place of work

Hartrampf Research Group
University of Zurich - Irchel Campus
Department of Chemistry
Winterthurerstrasse 190
8057 Zurich

Start of employment

The employment start date is flexible and will be mutually agreed upon. Your application should contain:Please submit your application until latest 20th March 2021 (incomplete applications will not be considered).

Further information