Institute for Regenerative Medicine - IREM

PhD Position
60 %

The gene therapy and immunology laboratory is associated to the IREM, a research institute from the University of Zurich localized at the new life-science campus in Schlieren. The mission of the Institute is to advancing molecular life sciences into next generation bio-inspired therapies for human diseases at the interface of degeneration and regeneration.

The gene therapy and immunology laboratory at IREM focusses on the pathophysiology of primary im-munodeficiencies (PIDs) and on the development of gene therapy systems that will be implemented in clinical trials for patients with severe, often mortal diseases, including PIDs.
Our institution is based on interdisciplinary, innovative and dynamic collaborations. You will profit from a systematic training on the job, in addition to personal development possibilities and our pronounced vocational training culture. The salary will be in the range recommended by the Swiss National Science Foundation.
The project objective is to elucidate the role of PD-1/PD-L1 checkpoint in host pathogen control and inflammatory responses. The interplay of reactive oxygen species, autophagy and immune checkpoints will be analyzed in human and mouse immune cells in vitro and in vivo. The project will start as soon as possible after January 2020.

For more information, please see:

Your responsibilities

•Elucidate the interplay of autophagy, ROS and PD-1/PD-L1 checkpoint upon influenza A or BCG infection
•Elucidate the impact of vesicular transport modulation on infection and inflammation
•Work with pathogens (BCG and influenza A) in human and mouse primary cells, and in vivo mice models
•Collaborating in a multidisciplinary research project with partners from UZH (project partner Prof. C. Münz, Institute for Experimental Immunology)

Your profile

•You hold an University diploma/MSc degree in immunology, molecular biology, biomedicine, pharmacology, or other relevant fields with excellent qualifications
•Experience in transgenic mouse models, stem cell biology, and standard techniques of molecu-lar biology and/or cell biology
•You are an enthusiastic and creative scientist interested to work in a very interdisciplinary envi-ronment within a transdisciplinary consortium of experts ranging from pharmacology, biochem-istry, molecular biology to clinical applications

What we offer

We offer an interesting working place in an international, diversified and dynamic academic environment.

Place of work

Schlieren, Wagistrasse 12

Start of employment

Employment start date April 1, 2020 or to be mutually agreed.

Further information