GMP Production Operator/Research Associate 80-100 %
The Wyss Zurich is a joint accelerator of the ETH Zurich and the University of Zurich, which was made possible by a generous donation from the Swiss entrepreneur and philanthropist Dr. hc. mult. Hansjörg Wyss. The mission of Wyss Zurich is to drive the clinical translation and technology transfer of outstanding scientific discoveries into new therapies for patients and breakthrough innovations in the emerging fields of Regenerative Medicine and Robotics, and to promote hybrid technologies in these fields. Wyss Zurich brings together some of the world's leading experts to form multidisciplinary teams, pooling their knowledge and expertise.
The project MUVON is developing a low-risk, minimally invasive treatment that uses the patient's own muscle precursor cells (MPC) to regenerate the damaged sphincter muscle, thus potentially providing a cure for stress urinary incontinence, as the first target indication. Currently being at the end of Phase I clinical trial, the MUVON project has been supported by Wyss Zurich and will now proceed with the clinical and commercial development of their therapy, evaluating the efficacy of the approach during a Phase II clinical trial and undertaking all the required activities for regulatory approval. We are a young, dynamic, energetic team with outstanding dedication to bringing a significant change in patient's lives and have recently founded the UZH Spin-off MUVON Therapeutics which is linked to this project.
We are looking for an ambitious and flexible GMP/Research Technician to support the production of an autologous cell product for use in a first-in-human clinical trial. The position will be clearly divided between GMP (50-60%) and Research and Development in the Lab (40-50%). You will be able to join a young and dynamic start-up team and will be working in a grade B cleanroom (in collaboration with Wyss Zurich, the facility at Moussonstrasse) to support the production of muscle precursor cells from patient biopsies in a GMP compliant manner. Furthermore, you will support ongoing research projects which aim to further improve the therapy being developed.
GMP-compliant cell production in the GMP cleanroom facility (primary cell production, analysis according to current GMP regulations, coordination)
Clear and structured data organization for precise documentation
Research and Development: assay development, process improvements for later-stage clinical trials (e.g. mammalian cell culture, WES, FACS, etc.), project organization and coordination (e.g. ordering, planning)
Education level: Biological lab technician or Bachelor's degree in Biology, Biotechnology, or a similar field
Strong experience in mammalian cell culture is mandatory
Open and ready to work in GMP cleanroom class B; previous GMP experience desirable
Precise working habits, strong attention to detail, and ability to work under time pressure
Flexible working times, willingness to commute between the lab (Schlieren) and GMP facility (ZH city)
Ability to plan and execute research projects independently and as part of the R&D/GMP team
Solid communication & writing skills in English and German required, French desirable
Command of Microsoft Office required, knowledge of Flow Jo and Image Analysis desired
What we offer
We are a young, energetic team with outstanding dedication to bringing a significant change in patient's lives. Therefore, we have founded the UZH Spin-off MUVON Therapeutics in 2020, which is linked to this position and the phase II study. Our goal is to further strengthen the GMP team for the phase II productions at the Wyss Zurich, as well as drive the development of our revolutionary therapy and also provide an opportunity to extend employment through MUVON Therapeutics and participation in Startup success.