Institute for Regenerative Medicine
Gene and cell therapy laboratory

1 Postdoctoral Fellow, 1 year
100 %

The gene and cell therapy laboratory is localized at the IREM, a research institute of the Universi-ty of Zurich at the life-science campus in Schlieren. The mission of the Institute is advancing mo-lecular life sciences into next generation of bio-inspired therapies for human diseases at the inter-face of degeneration and regeneration.

The gene and cell therapy laboratory is developing viral and non-viral gene therapy vectors with the goal to implement new gene therapy systems in clinical trials for patients with severe, often fatal diseases.
Our research is based on interdisciplinary, innovative and dynamic collaborations between scien-tists and clinicians. You will profit from a systematic hands-on training, in addition to personal de-velopment possibilities and our pronounced vocational training culture. The salary is in the range recommended by the Swiss National Science Foundation. It is expected that the postdoctoral re-searcher contributes to PhD student supervision and applies for additional third-party funding for later project prolongation.
The project objectives are 1) to generate proof-of-principle data concerning novel lentiviral-self-inactivated gene therapy vectors for the treatment of cancer (first 6 months), and if successful in-vitro to 2) continue the development with in-vivo data for later clinical application. The project is linked to the HMZ flagship Immuno-TargET (https://www.hochschulmedizin.uzh.ch/de/projekte/immunotarget.html) and will start in October 2020.

Your responsibilities

Test and eventually improve novel lentiviral gene therapy vectors in primary derived cells, cell lines, and mouse models
Establish tumor/immune cell coculture models

Your profile

You hold a doctoral degree (PhD, or MD/PhD) and a University diploma in immunology, molecular biology, biomedicine, pharmacology, or other relevant fields with excellent quali-fications; post-doctoral experience in the field of oncology/cancer is of advantage
Track record of active research preferably in cancer research or in gene therapy, stem cell biology, as evidenced by high quality publications
Experience with lentiviral vectors, transgenic mouse models, stem cell biology, and stand-ard techniques of molecular biology and/or cell biology
You are an enthusiastic and creative scientist interested to work in a collaborative envi-ronment within a consortium of experts ranging from pharmacology, biochemistry, molecu-lar biology to clinical applications
You are highly motivated by the successful translation of basic science research into clini-cal trials and products