Institute of Pharmacology and Toxicology
Senior Research Associate, In Vivo Pharmacology (Immuno-Oncology) 80 - 100 %
Start of employment Immediate start or to be mutually agreedThe group of Prof. Schwank is working on translational genome editing and cell-based therapies. We are seeking an experienced Research Associate (80-100%) to drive the in vivo components of a translational research program developing in vivo CAR T cell therapies based on RNA–lipid nanoparticle technology.
The successful candidate will independently execute and analyze preclinical studies in humanized and syngeneic tumor models, contributing directly to milestone delivery within a translational research program.
Your responsibilities
You will work closely with the Molecular Biology and RNA-Delivery teams to produce milestone-ready, in vivo da-tasets demonstrating in vivo CAR-T generation and antitumor activity in humanized and syngeneic models. The role combines hands-on animal experimentation, sample processing, and immunological analysis. You will be responsible for planning and executing tumor studies in humanized and syngeneic mouse models as well as per-forming follow-up analyses such as flow cytometry, cytokine profiling, and histological readouts.
Your profile
Candidates may come from various educational paths; relevant combinations of education and experience are equally valued. The candidate has at least a
- MSc in Biology, Biotechnology, Immunology, Pharmacology, or related field, with more than 3 years of relevant experience, or
- BSc in Life Sciences with more than 5 years of relevant experience.
- Extensive hands-on experience with mouse handling, including NSG or other immunodeficient strains.
- Proficiency in liquid (e.g. NALM-6) and solid tumor studies.
- Robust expertise with intravenous (IV), intraperitoneal (IP) and subcutaneous (SQ) injections of laborato-ry rodents.
- Strong tail vein intravenous dosing expertise is required.
- Demonstrated ability to perform flow cytometric experiments including sample preparation, staining, and basic data analysis.
- Experience with tumor immunology, immune-cell isolation, and ex vivo functional assays.
- Valid FELASA B/C or LTK 1/2 animal license (or equivalent).
- Strong organizational skills, attention to detail, and ability to work autonomously within project time-lines.
- Excellent record-keeping and data management skills; able to compile results for internal reports.
- Familiarity with RNA or nanoparticle-based therapeutics is a plus.
- Experience with longitudinal imaging and biodistribution studies is a plus.
- Prior exposure to GLP-like preclinical documentation or biotech environments is a plus.
Information on your application
Please apply with a single PDF (CV, brief cover letter) to Dr. Andreas Reichmuth. Applications will be reviewed on a rolling basis.What we offer
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Working at UZH
The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer!
More → https://www.uzh.ch/en/explore/work.html
Please apply via our job portal www.jobs.uzh.ch.
The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer!
More → https://www.uzh.ch/en/explore/work.html
Please apply via our job portal www.jobs.uzh.ch.
Working at UZH
The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer!
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