Schwank Lab, Institute of Pharmacology, University of Zurich
Research Associate in In Vivo Genome Editing 80 - 100 %
Start of employment as soon as possible or upon agreementThe Schwank Lab at the University of Zurich develops and translates next-generation genome-engineering technologies toward therapeutic applications. Our interdisciplinary research combines CRISPR-based genome editing, advanced delivery technologies, disease models, and preclinical studies, with major programmes in metabolic liver diseases, neurological disorders, and immune-cell engineering. A particular focus is the development of genome-editing therapies for urea cycle disorders, and we are currently advancing selected programmes toward clinical translation.
Your responsibilities
- Plan, coordinate and conduct in vivo studies in mouse models of genetic liver disease required for the initiation of clinical trials.
- Administer genome-editing therapeutics and other test substances using relevant routes of delivery.
- Perform animal monitoring, blood and tissue collection, necropsies, organ harvesting and downstream sample processing.
- Perform molecular and cellular biology experiments, including mammalian cell culture, DNA and RNA isolation, PCR/qPCR, cloning and preparation of samples for sequencing.
- Analyse, interpret and document experimental results and contribute to the optimisation of experimental protocols.
- Maintain accurate records and ensure that all animal experiments are conducted in accordance with approved protocols and Swiss animal-welfare regulations.
- Collaborate closely with scientists, students and external project partners across several parallel research projects.
Your profile
- BSc or MSc in molecular biology, biotechnology, biomedicine, veterinary medicine, pharmaceutical sciences or a related discipline.
- Substantial hands-on experience conducting experiments with mice is essential.
- Candidates should be confident in animal handling and in relevant experimental procedures such as dosing/injections, monitoring, blood sampling, tissue collection and necropsy.
- Strong practical experience in molecular and cellular biology (cloning, cell culture) and careful handling of biological samples.
- Experience with CRISPR genome editing, RNA therapeutics, lipid nanoparticles, viral vectors, liver biology or metabolic disease models is an advantage but not required.
- Ability to organise and conduct experiments independently, troubleshoot procedures and contribute effectively to multiple projects.
- A highly reliable, precise and collaborative working style, with strong attention to animal welfare and experimental documentation.
- Good written and spoken English.
Information on your application
Please submit your application as a single PDF containing a motivation letter, curriculum vitae, relevant certificates (including laboratory-animal training, where applicable) and contact details for two referees.What we offer
Our employees benefit from a wide range of attractive offers. Find out more: https://www.uzh.ch/de/explore/work.html.
What we offer
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Gerald Schwank Professor, Group Leader
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Working at UZH
The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer!
More → https://www.uzh.ch/en/explore/work.html
Please apply via our job portal www.jobs.uzh.ch.
The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer!
More → https://www.uzh.ch/en/explore/work.html
Please apply via our job portal www.jobs.uzh.ch.
Working at UZH
The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer!
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